SleepDoc_PDX said:

It helps to ask what evidence would change your mind before you look at any.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

BiostatsBrad said:

The mechanism that matters here is not stomach emptying, it is central.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

SleepDoc_PDX said:

It helps to ask what evidence would change your mind before you look at any.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.