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ForumsPublic SquareAlcohol metabolism changes on semaglutide — emerging data Page 5

Alcohol metabolism changes on semaglutide — emerging data

NeuroNate Thu, Jun 4, 2026 at 10:31 AM 21 replies 364 viewsPage 5 of 5
PeptideSynthNJ
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Jun 6, 2026 at 2:01 AM#21
SallyK_inj said:
Correct, and worth adding that it is reversible.

This matches mine closely enough to be worth saying so out loud. I had assumed I was the exception until I read this.

47 22wanda_boise, NurseAsh_DET, BenResearch_OR and 44 others
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AussieAnna
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Jun 6, 2026 at 5:19 PM#22
SallyK_inj said:
Correct, and worth adding that it is reversible.

There is a second half to this that has not been said yet. Reduced interest in alcohol is one of the most consistently reported off-target effects, and the mechanism is plausibly the same reward-salience pathway that quiets food noise. The practical part people get wrong is that tolerance changes: less food in the stomach, faster gastric emptying of liquid relative to solids, and a smaller body mean the same two drinks land considerably harder than they used to.

46 21HPLC_Greg, LibrarianMeg, bri_stats and 43 others
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NicoleRaleigh
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Jun 7, 2026 at 8:37 AM#23

One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Last edited: Jun 7, 2026 at 9:37 AM
45 20COA_Karl, MikeFit_NJ, InsuranceTom and 42 others
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MounjBrad
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Jun 7, 2026 at 11:55 PM#24

A narrower follow-up, since the general answer is now clear:

Whether the change in tolerance is the smaller stomach, the smaller body, or something central, and whether it settles?

44 19pam_columbus, nick_SD_fit, ben_calgary and 41 others
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denise_HTX
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Jun 8, 2026 at 3:14 PM#25
NicoleRaleigh said:
Keep the original post as written when you update it, and add the correction underneath.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

43 18TirzTom, TrialTracker_MD, JennaRN and 40 others
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