Apr 28, 2026 at 11:07 AM#16
Dr.EndoIndy said:Maintenance phase reality on maintenance dosing: reached my goal 8 months ago and now I'm in maintenance.
Second this.
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Apr 28, 2026 at 2:36 PM#17
HPLC_Greg said:The concept of "metabolic set point" and its relevance to maintenance dosing: the body actively defends a weight set point through hormonal feedback…
Epigenetic implications of GLP-1 therapy and maintenance dosing: emerging evidence suggests that sustained weight loss and metabolic improvement may produce epigenetic changes (DNA methylation, histone modification) that persist beyond drug discontinuation[1].
This is speculative but fascinating: could long-term GLP-1 agonist treatment "reprogram" metabolic gene expression? If so, it would explain why some patients maintain weight loss better than others after discontinuation.
More research needed, but the concept of pharmacologically-induced epigenetic remodeling is intellectually exciting.
References:
[1] Ling C, et al. Diabetologia. 2023;66(6):1078-1093.
[1] Ling C, et al. Diabetologia. 2023;66(6):1078-1093.
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Apr 28, 2026 at 6:05 PM#18
HPLC_Greg said:The concept of "metabolic set point" and its relevance to maintenance dosing: the body actively defends a weight set point through hormonal feedback…
That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.
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View ResultsApr 28, 2026 at 9:34 PM#19
HPLC_Greg said:The concept of "metabolic set point" and its relevance to maintenance dosing: the body actively defends a weight set point through hormonal feedback…
Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.
Last edited: Apr 29, 2026 at 12:34 AM
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Apr 29, 2026 at 1:03 AM#20
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.
Last edited: Apr 29, 2026 at 5:03 AM
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