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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 7

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 7 of 9
matt_MKE
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Feb 21, 2025 at 2:27 PM#31

Following on from Dr.CardioMD — and this may be the naive question:

What would you measure differently if you were starting again?

5 3andrew_nyc, Dr.EndoEP, GraceAZ_72 and 2 others
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MounjBrad
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Oct 2024
Kentucky
Feb 23, 2025 at 1:18 AM#32
Dr.EM_Chicago said:
I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

6 4ben_calgary, patPC_UT, Dr.DermMIA and 3 others
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zoe_NC
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Nov 2024
Charlotte, NC
Feb 24, 2025 at 12:09 PM#33
Dr.EM_Chicago said:
I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Feb 24, 2025 at 1:09 PM
7 5james_edin, FranDenver, Dr.BariatricHTX and 4 others
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A1cHero_PHX
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Phoenix, AZ
Feb 25, 2025 at 10:59 PM#34
Dr.EM_Chicago said:
I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

8 6chris_chi24, tampaLisa73, KarenAZ_mom and 5 others
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JenPlateau
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Nov 2024
Missouri
Feb 27, 2025 at 9:48 AM#35

From the other side of the consultation, briefly. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

9 7sarah_nash92, FitDadDave, RunnerRach and 6 others
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