lisa_labSD said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

lisa_labSD said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

Clinical perspective, offered as context rather than as advice. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

carl_compliance said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Adding a me-too, because a thread of one person's experience is not much use.

Closing the loop on my own question.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.