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ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 5

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Sat, Oct 19, 2024 at 12:13 AM 31 replies 2,377 viewsPage 5 of 7
raj_cambridge
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Oct 22, 2024 at 4:37 PM#21

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: Oct 22, 2024 at 5:37 PM
3 1SleepFixSam, PurityPaulOR, MaxMetOK
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CryptoCarl
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Oct 23, 2024 at 8:25 AM#22

Following on from roxy_nash — and this may be the naive question:

How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?

Last edited: Oct 23, 2024 at 12:25 PM
4 2MariaRD, AussieAnna, BethLabQueen and 1 other
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sean_dublin
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Oct 24, 2024 at 12:12 AM#23
raj_cambridge said:
If you are going to change something, change one thing and give it long enough to express itself.

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

5 3gary_naperville, sean_dublin, hannah_MT and 2 others
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PurityPaulOR
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Oct 24, 2024 at 3:59 PM#24
raj_cambridge said:
If you are going to change something, change one thing and give it long enough to express itself.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Happy to go further on any of that.

6 4Dr.Martinez, mike_mod, SarahChen_PharmD and 3 others
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A1cHero_PHX
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Oct 25, 2024 at 7:46 AM#25
raj_cambridge said:
If you are going to change something, change one thing and give it long enough to express itself.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

7 5jason_sac26, chris_chi24, tampaLisa73 and 4 others
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