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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralAnyone else feel guilty for using a drug to lose weight? — looking for input Page 2

Anyone else feel guilty for using a drug to lose weight? — looking for input

FranDenver Mon, Nov 24, 2025 at 9:59 PM 14 replies 1,143 viewsPage 2 of 3
Dr.PainCLE
Senior Member
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Cleveland, OH
Nov 25, 2025 at 4:40 PM#6
CarlaRPh_TPA said:
Body image adjustment with mental health: I've lost 75 lbs but when I look in the mirror, I still see my old self sometimes.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

50 20Dr.PathRoch, mona_PHX, andrew_nyc and 47 others
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PeptideChemSF
Senior Member
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Jan 2024
San Francisco, CA
Nov 26, 2025 at 12:06 AM#7
FranDenver said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…
FranDenver said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

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newstart_MO
New Member
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Feb 2026
Springfield, MO
Nov 26, 2025 at 7:32 AM#8
Dr.PainCLE said:
I would be careful about how confidently the flatness reports get attributed.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
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WendyG_ATL
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Georgia
Nov 26, 2025 at 2:58 PM#9

A narrower follow-up, since the general answer is now clear:

Was that from a primary source or from a summary of one?

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FranDenver
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Oct 2024
Denver, CO
Nov 28, 2025 at 2:39 AM#10

Reporting back.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

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