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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHow far away are we really from an oral option — my results so far Page 2

How far away are we really from an oral option — my results so far

MounjBrad Sun, Aug 4, 2024 at 1:20 PM 17 replies 2,175 viewsPage 2 of 4
PharmD_Rodriguez
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Aug 4, 2024 at 3:08 PM#6
LipidDoc_ATL said:
Orforglipron is the more interesting oral story because it is not a peptide at all.

I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.

Last edited: Aug 4, 2024 at 8:08 PM
45 15paul_denver, TinaHashiRN, robert_kc and 42 others
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VendorMark
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Aug 4, 2024 at 3:50 PM#7

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Aug 4, 2024 at 5:50 PM
44 14KristenIndy, MarkLI_maint, Dr.PeteFamMed and 41 others
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BariatricNurseD
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Aug 4, 2024 at 4:32 PM#8
PharmD_Rodriguez said:
I do not accept that the fasting window is a minor inconvenience.

Coming at PharmD_Rodriguez’s question from a different direction. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Last edited: Aug 4, 2024 at 9:32 PM
43 13josh_phd_bmore, roxy_nash, tony_orlando and 40 others
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steve_okc
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Aug 4, 2024 at 5:14 PM#9

A narrower follow-up, since the general answer is now clear:

Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?

Last edited: Aug 4, 2024 at 9:14 PM
42 12CanadaChris, ZaraB_AL, JakeSmashed95 and 39 others
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MounjBrad
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Aug 4, 2024 at 8:35 PM#10

Closing the loop on my own question.

Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.

22 22marco_milano, pam_columbus, nick_SD_fit and 19 others
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