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ForumsPsychological & BehavioralGLP-1 and addiction pathways — anyone have experience?

GLP-1 and addiction pathways — anyone have experience?

sean_dublin Sun, Oct 12, 2025 at 7:36 PM 10 replies 1,203 viewsPage 1 of 2
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sean_dublin
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Oct 12, 2025 at 7:36 PM#1

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

What I am trying to establish is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Happy to be told the question itself is wrong.

50 20hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 47 others
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TrialNerd_Beth
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Bethesda, MD
Oct 12, 2025 at 9:35 PM#2
sean_dublin said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about whether I deserved to feel good.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

49 19PharmHunterJen, TomTeleRx, DoseLogDan and 46 others
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pam_stl
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St. Louis, MO
Oct 12, 2025 at 11:34 PM#3
TrialNerd_Beth said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

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RegAffairsDC
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Oct 13, 2025 at 1:33 AM#4
sean_dublin said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Mine went the same way, slower. Posting only so the count is not one.

Last edited: Oct 13, 2025 at 3:33 AM
47 17sean_dublin, hannah_MT, Dr.SportsMedIN and 44 others
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Dr.EndoIndy
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Indianapolis, IN
Oct 13, 2025 at 1:17 PM#5

From the other side of the consultation, briefly.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Oct 13, 2025 at 4:17 PM
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