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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — any impact on this risk factor?

Lp(a) on GLP-1 agonists — any impact on this risk factor?

LipidDoc_ATL Sun, Jun 7, 2026 at 7:49 AM 8 replies 202 viewsPage 1 of 2
LipidDoc_ATL
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Apr 2024
Atlanta, GA
Jun 7, 2026 at 7:49 AM#1

Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been promised.

What I am after is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

37 7rachel_ABQ, traveltech_sara, AttorneyGrant and 34 others
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LabKate
Senior Member
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Jan 2024
Oregon
Jun 7, 2026 at 7:55 AM#2
LipidDoc_ATL said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.0% to 8.0% over 13 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

36 6laura_annarbor, JenMemphis, pat_auckland and 33 others
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traveltech_sara
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Jan 2025
Remote, USA
Jun 7, 2026 at 8:01 AM#3
LabKate said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.0% to 8.0% over 13 months.

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 10moChange
MetabolicA1C7.4%5.6%⬇️ 1.6%
MetabolicFasting Glucose13287⬇️ 32
LipidsLDL17099⬇️ 42
LipidsTriglycerides242122⬇️ 92
InflammationhsCRP7.51.0⬇️ 5.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

Last edited: Jun 7, 2026 at 11:01 AM
35 5wanda_boise, NurseAsh_DET, BenResearch_OR and 32 others
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NauseaFreeNow
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Aug 2024
Indiana
Jun 7, 2026 at 8:07 AM#4
LipidDoc_ATL said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Mine went the same way, slower.

34 4lori_vegas, Dr.PulmRoch, maya_sedona and 31 others
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PedsEndoPhilly
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Jun 2024
Philadelphia, PA
Jun 7, 2026 at 8:35 AM#5

Clinical perspective, offered as context rather than as advice.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1549949Particle count (more precise than LDL-C)
Small dense LDL59%33%Atherogenic pattern
Remnant cholesterol3318Triglyceride-rich lipoproteins
oxLDL7447Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

Last edited: Jun 7, 2026 at 1:35 PM
33 3MikeNYC_runner and 30 others
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