Dr.ReproEndo said:Orforglipron is the more interesting oral story because it is not a peptide at all.
That reframing is the part I needed.
Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
TrialNerd_Beth said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.
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Shop Reference StandardsAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. No action needed from anybody.