sarah_TO said:

The GIP arm is doing real work rather than padding the label.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

DeniseRN_TPA said:

The class is not used in pregnancy, and the practical points are a washout before conception and the fact that reduced appetite is not contraception.

Pushing back on DeniseRN_TPA here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

That is the short version; the long version is somebody else's post.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.