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ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — my results so far Page 7

Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

raj_cambridge Mon, Dec 15, 2025 at 6:20 AM 33 replies 1,411 viewsPage 7 of 7
VanRx_Mike
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Jan 1, 2026 at 4:21 AM#31

Following on from lisa_labSD — and this may be the naive question:

How long did you give it before you decided it was working?

49 24Dr.LeslieOBGYN, MikeNYC_runner and 46 others
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RetaRick_CA
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Jan 2, 2026 at 10:33 AM#32
raj_cambridge said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Pushing back on raj_cambridge here. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

48 23AmyNC_wife, SkepticalSean, Dr.CardioMD and 45 others
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Dr.RaviCardio
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Jan 3, 2026 at 4:44 PM#33
raj_cambridge said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

47 22mark_tokyo, hans_munich, jason_sac26 and 44 others
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wendy_avl
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Jan 4, 2026 at 10:55 PM#34
raj_cambridge said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

That reframing is the part I needed.

Last edited: Jan 5, 2026 at 4:55 AM
46 21PharmHunterJen, TomTeleRx, DoseLogDan and 43 others
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NurseKim_ATL
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Jan 6, 2026 at 5:05 AM#35

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Jan 6, 2026 at 10:05 AM
45 20hank_denver, carlos_SATX, sophie_paris and 42 others
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