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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-2: tirzepatide for T2DM + obesity — dual indication results Page 4

SURMOUNT-2: tirzepatide for T2DM + obesity — dual indication results

Dr.MetabolicMD Mon, May 25, 2026 at 6:35 AM 18 replies 466 viewsPage 4 of 4
nick_newbie
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Jun 2, 2026 at 7:16 PM#16
Dr.NephBHM_UK said:
Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This is my experience too, for whatever a second data point is worth. Nothing to add that would improve it.

25 0robert_kc, dan_philly, MeganSA_TX and 22 others
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CarlaRPh_TPA
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Jun 4, 2026 at 1:22 AM#17
Dr.AddMedPHL said:
Practical: whatever you change, write down the date and the reason.

Mine went the same way, slower. I had assumed I was the exception until I read this.

24 24ricardo_MIA, BrianDallas92, labquiet_amy and 21 others
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FranDenver
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Jun 5, 2026 at 7:29 AM#18
Dr.AddMedPHL said:
Practical: whatever you change, write down the date and the reason.

Coming at Dr.AddMedPHL’s question from a different direction. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

23 23BariatricNurseD, MASHdoc_SA, GenomicsKate and 20 others
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HPLC_Greg
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Jun 6, 2026 at 1:36 PM#19

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Last edited: Jun 6, 2026 at 7:36 PM
22 22Dr.MetabolicMD, RetaRick_CA, JenPlateau and 19 others
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mike_mod
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Jun 7, 2026 at 7:44 PM#20

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

50 0PurityPaulOR, MaxMetOK, MounjBrad and 47 others
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