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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide and fatty liver — SURPASS hepatic substudies Page 4

Tirzepatide and fatty liver — SURPASS hepatic substudies

MASHdoc_SA Thu, May 14, 2026 at 8:13 AM 19 replies 656 viewsPage 4 of 4
MaxMetOK
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May 25, 2026 at 12:54 PM#16
Dr.SurgeonPGH said:
Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This is my experience too, for whatever a second data point is worth.

42 17PharmHunterJen, TomTeleRx, DoseLogDan and 39 others
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pete_RVA
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May 26, 2026 at 5:48 PM#17

Following on from Dr.RaviCardio — and this may be the naive question:

Whether normalised enzymes tell you anything about fibrosis, and what the right follow-up measurement is?

Last edited: May 26, 2026 at 10:48 PM
41 16Dr.Martinez, mike_mod, SarahChen_PharmD and 38 others
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Dr.NephBHM_UK
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May 27, 2026 at 10:42 PM#18
SleepDoc_PDX said:
Worth stating the units and the reference range whenever you post a number here.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

40 15PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 37 others
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Dr.ReproEndo
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May 29, 2026 at 3:37 AM#19
SleepDoc_PDX said:
Worth stating the units and the reference range whenever you post a number here.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Last edited: May 29, 2026 at 4:37 AM
39 14GraceAZ_72, carl_compliance, DanielChem_CHI and 36 others
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Admin
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May 30, 2026 at 8:32 AM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. No action needed from anybody.

Last edited: May 30, 2026 at 12:32 PM
17 17PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 14 others
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