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ForumsTirzepatide (Mounjaro / Zepbound)GIP receptor: the underappreciated half of tirzepatide's mechanism Page 4

GIP receptor: the underappreciated half of tirzepatide's mechanism

NeuroNate Sat, May 9, 2026 at 2:22 AM 19 replies 575 viewsPage 4 of 4
stefan_berlin
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May 10, 2026 at 9:53 AM#16
JenPlateau said:
Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This matches mine closely enough to be worth saying so out loud. I had assumed I was the exception until I read this.

Last edited: May 10, 2026 at 12:53 PM
25 0NeuroNate, JessicaH_TX, KevinCompounds and 22 others
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Dr.RenalNash
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May 10, 2026 at 2:18 PM#17
PeptideChemSF said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Ask again with the specifics and you will get a better answer than this one.

24 24pam_stl, wei_SG, cory_ATX and 21 others
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SandraNC_45
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Charlotte, NC
May 10, 2026 at 6:43 PM#18
PeptideChemSF said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

23 23NicoleRaleigh, james_edin, FranDenver and 20 others
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hank_denver
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May 10, 2026 at 11:09 PM#19
PeptideChemSF said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

22 22fiona_VT, denise_HTX, raj_cambridge and 19 others
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mike_mod
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May 11, 2026 at 3:35 AM#20

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Thread quality here is what the rules are for. Keep it up.

Last edited: May 11, 2026 at 5:35 AM
50 0PurityPaulOR, MaxMetOK, MounjBrad and 47 others
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