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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirz made me a completely different person holy cow Page 3

Tirz made me a completely different person holy cow

ZaraB_AL Thu, Apr 16, 2026 at 7:50 PM 26 replies 743 viewsPage 3 of 6
kate.chem
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Apr 18, 2026 at 12:59 PM#11
Dr.GastroMayo said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

30 5steve_okc, dave_SLC, FDA_TrackerJim and 27 others
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FranDenver
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Apr 18, 2026 at 4:43 PM#12
GenomicsKate said:
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

Last edited: Apr 18, 2026 at 10:43 PM
29 4LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 26 others
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Dr.RheumBOS
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Apr 18, 2026 at 8:27 PM#13
Dr.GastroMayo said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

I read this differently from Dr.GastroMayo, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Last edited: Apr 19, 2026 at 2:27 AM
28 3cory_ATX, lori_vegas, Dr.PulmRoch and 25 others
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Dr.PeteFamMed
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Apr 19, 2026 at 12:11 AM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Apr 19, 2026 at 1:11 AM
27 2Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 24 others
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mike_mod
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Apr 19, 2026 at 3:54 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

26 1PurityPaulOR, MaxMetOK, MounjBrad and 23 others
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