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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralAnyone else feel guilty for using a drug to lose weight? — anyone have experience? Page 2

Anyone else feel guilty for using a drug to lose weight? — anyone have experience?

Dr.GastroMayo Wed, Mar 5, 2025 at 3:04 PM 6 replies 1,583 viewsPage 2 of 2
RetaRick_CA
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Mar 6, 2025 at 10:36 AM#6
DebRD_ATL said:
Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

This is where I part company with the consensus forming above. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

Correct me if the detail matters more than I have assumed.

50 20SkepticalSean, Dr.CardioMD, EndoResFellow and 47 others
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raj_cambridge
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Mar 6, 2025 at 6:22 PM#7
Dr.GastroMayo said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

Last edited: Mar 6, 2025 at 7:22 PM
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PharmacoVig_BOS
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Mar 7, 2025 at 2:08 AM#8
RetaRick_CA said:
I would be careful about how confidently the flatness reports get attributed.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

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ricardo_MIA
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Mar 7, 2025 at 9:54 AM#9

One thing that is still open after VanRx_Mike’s answer:

What would you measure differently if you were starting again?

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Dr.GastroMayo
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Mar 8, 2025 at 11:14 PM#10

Closing the loop on my own question.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

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