Dr.SurgeonPGH said:

They are two different exemptions from the same federal requirements and they buy different things.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

Clinical perspective, offered as context rather than as advice.

GMP compliance checklist relevant to compounded supply compounding quality:

• Clean room environment with HEPA filtration
• Environmental monitoring (viable and non-viable)
• Personnel training and competency assessment
• Validated analytical methods for testing
• Stability testing program
• Complete batch records and traceability
• Quality management system with deviation handling

A 503B pharmacy following cGMP should be able to answer questions about ALL of these if you ask. Don't be afraid to ask — it's your health.

KevinCompounds said:

Compounding pharmacy red flag checklist for compounded supply — if ANY of these apply, find a different source: No verifiable physical address No…

Compounded has been just as effective for me. If compounded supply is the concern, the COA from my 503B pharmacy shows 99.1% purity. Verified by Janoshik.

Dr.RaviCardio said:

Resolution therefore closed the doors unevenly, and the asymmetry follows from the bulks lists.

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both. The key is finding a reliable 503B pharmacy with independent testing.

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.