kate.chem said:

The GIP arm is doing real work rather than padding the label.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

sarah.morrison said:

The "tirzepatide is simply better" summary irritates me.

There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Following on from wanda_boise — and this may be the naive question:

Whether anyone has held 10mg long term rather than climbing, and what happened over the following year?

Reporting back.

Update: the eight-week restart pattern people described is exactly what happened. I nearly abandoned it at week five.