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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 4

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Sat, Mar 14, 2026 at 9:46 PM 36 replies 1,552 viewsPage 4 of 8
LibrarianMeg
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Mar 18, 2026 at 4:41 AM#16

From the other side of the consultation, briefly. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Last edited: Mar 18, 2026 at 6:41 AM
11 9Dr.NateNeph, PharmD_Rodriguez, julia.endo and 8 others
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raj_cambridge
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Mar 18, 2026 at 4:53 PM#17

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Mar 18, 2026 at 5:53 PM
12 10DoseLogDan, SleepFixSam, PurityPaulOR and 9 others
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PedsEndoPhilly
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Mar 19, 2026 at 5:04 AM#18

Following on from lisa_labSD — and this may be the naive question:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

Last edited: Mar 19, 2026 at 10:04 AM
13 11jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 10 others
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JenMemphis
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Mar 19, 2026 at 5:15 PM#19
raj_cambridge said:
Worth stating the units and the reference range whenever you post a number here.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

14 12wanda_boise, NurseAsh_DET, BenResearch_OR and 11 others
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Admin
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Mar 20, 2026 at 5:26 AM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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