SleepDoc_PDX said:

Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

hank_denver said:

TrialTracker_MD said: ...regarding the trial evidence...

Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.