Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
A narrower follow-up, since the general answer is now clear:
What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?
claudia_zurich said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
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Shop Reference Standardsclaudia_zurich said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.
Happy to go further on any of that.