Dr.LeslieOBGYN said:Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…
This matches mine closely enough to be worth saying so out loud.
jason_paloalto said:One habit that pays for itself: post the method alongside the number.
Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.
jason_paloalto said:One habit that pays for itself: post the method alongside the number.
Adding the part of the answer the thread has not reached. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
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View ResultsOne concrete data point for the thread. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.
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