Dr.LipidDallas said:

Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

tony_orlando said:

Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

Dr.LipidDallas said:

Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Ask again with the specifics and you will get a better answer than this one.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

That is the short version; the long version is somebody else's post.

Moderator note: a couple of off-topic posts removed.