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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and fatty liver? Page 3

Has anyone dealt with tirzepatide and fatty liver?

Dr.PeteFamMed Tue, Nov 18, 2025 at 6:29 PM 39 replies 1,964 viewsPage 3 of 8
amsterdam_pete
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Nov 19, 2025 at 6:33 AM#11
Dr.LeslieOBGYN said:
The liver data is among the strongest non-weight findings in the class.

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

20 20JakeSmashed95, NauseaFreeNow, SteveThurs and 17 others
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chris_chi24
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Nov 19, 2025 at 1:15 PM#12
hans_munich said:
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.

This is exactly what I could not find anywhere else.

Last edited: Nov 19, 2025 at 4:15 PM
19 19MounjBrad, nick_newbie, DadBodDave and 16 others
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TinaHashiRN
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Nov 19, 2025 at 7:57 PM#13
Dr.LeslieOBGYN said:
The liver data is among the strongest non-weight findings in the class.

I read this differently from Dr.LeslieOBGYN, on substance rather than tone. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

18 18Dr.Martinez, mike_mod, SarahChen_PharmD and 15 others
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wendy_avl
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Nov 20, 2025 at 2:40 AM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

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mike_mod
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Nov 20, 2025 at 9:23 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

16 16PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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