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ForumsPublic SquareMy 18-month semaglutide journey — 6 month update Page 7

My 18-month semaglutide journey — 6 month update

DerekSJ_a1c Tue, Jul 9, 2024 at 12:52 PM 39 replies 2,429 viewsPage 7 of 8
raj_cambridge
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Dec 28, 2024 at 12:57 PM#31
NurseLeah_Nash said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

There is a second half to this that has not been said yet. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

I would rather be corrected than agreed with, if it comes to it.

31 6SleepFixSam, PurityPaulOR, MaxMetOK and 28 others
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josh_phd_bmore
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Jan 11, 2025 at 12:33 PM#32

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Happy to go further on any of that.

30 5Dr.ObesityLA, NurseKim_ATL, paul_denver and 27 others
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DanielChem_CHI
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Jan 25, 2025 at 12:17 PM#33

Following on from NurseLeah_Nash — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

29 4patPC_UT, Dr.DermMIA, fiona_VT and 26 others
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FranDenver
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Oct 2024
Denver, CO
Feb 8, 2025 at 12:09 PM#34
josh_phd_bmore said:
Say what you would expect to see if you were wrong, before you look.

This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Happy to go further on any of that.

28 3MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 25 others
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AussieAnna
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Feb 8, 2025 at 6:09 PM#35
josh_phd_bmore said:
Say what you would expect to see if you were wrong, before you look.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

27 2pete_manc_UK, anna.melb_AU, mark_tokyo and 24 others
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