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ForumsTirzepatide (Mounjaro / Zepbound)Switching from sema to tirz and WOW the difference — what worked for you? Page 3

Switching from sema to tirz and WOW the difference — what worked for you?

COA_Karl Thu, Aug 7, 2025 at 10:38 PM 13 replies 1,517 viewsPage 3 of 3
Dr.MetabolicMD
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Aug 8, 2025 at 11:00 AM#11
PedsEndoPhilly said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Last edited: Aug 8, 2025 at 1:00 PM
24 24SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 21 others
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kevin_tulsa
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Aug 8, 2025 at 5:50 PM#12
hans_munich said:
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

23 23Dr.RheumBOS, greg_boulder, quinn_sf and 20 others
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tommy_boulder
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Aug 9, 2025 at 12:40 AM#13
PedsEndoPhilly said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

22 22robert_kc, dan_philly, MeganSA_TX and 19 others
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bri_stats
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Aug 9, 2025 at 7:30 AM#14

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

21 21JessicaM_2024, TomFromTexas, mike.trainer_LA and 18 others
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mike_mod
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Aug 9, 2025 at 2:21 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

Last edited: Aug 9, 2025 at 4:21 PM
20 20PurityPaulOR, MaxMetOK, MounjBrad and 17 others
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