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ForumsClinical Trials & ResearchFLOW trial: semaglutide renal outcomes — need advice Page 5

FLOW trial: semaglutide renal outcomes — need advice

Dr.PainCLE Thu, Apr 16, 2026 at 9:08 PM 30 replies 843 viewsPage 5 of 6
dan_philly
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Apr 26, 2026 at 1:35 PM#21
mia_MS2 said:
Whether it is right for the case being asked about depends on a detail that has not been given.

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

Last edited: Apr 26, 2026 at 4:35 PM
1 1DadBodDave
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MeganSA_TX
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Apr 28, 2026 at 8:47 PM#22
mia_MS2 said:
Whether it is right for the case being asked about depends on a detail that has not been given.

There is a second half to this that has not been said yet. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".

50 0julia.endo, JessicaM_2024, TomFromTexas and 47 others
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PharmacoVig_BOS
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May 1, 2026 at 4:00 AM#23

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: May 1, 2026 at 7:00 AM
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NauseaFreeNow
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May 3, 2026 at 11:15 AM#24

Following on from mia_MS2 — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

48 23lori_vegas, Dr.PulmRoch, maya_sedona and 45 others
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MaxMetOK
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May 5, 2026 at 6:31 PM#25
PharmacoVig_BOS said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Pushing back on PharmacoVig_BOS here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

47 22PurityPaulOR, MaxMetOK, MounjBrad and 44 others
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