dan_philly said:Practical: whatever you change, write down the date and the reason.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
Adding the clinical framing, because it changes how the question reads. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
VendorMark said:Start from the measurement rather than the conclusion.
This matches mine closely enough to be worth saying so out loud.
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View ResultsVendorMark said:Start from the measurement rather than the conclusion.
There is a second half to this that has not been said yet. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.