SleepDoc_PDX said:

The mechanism is more central than most summaries suggest.

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

Ask again with the specifics and you will get a better answer than this one.

tampaLisa73 said:

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

SleepDoc_PDX said:

The mechanism is more central than most summaries suggest.

Pushing back on SleepDoc_PDX here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Ask again with the specifics and you will get a better answer than this one.

Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.