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ForumsTirzepatide (Mounjaro / Zepbound)Zepbound insurance coverage — what worked for you?

Zepbound insurance coverage — what worked for you?

TomFromTexas Mon, May 26, 2025 at 5:07 AM 10 replies 1,530 viewsPage 1 of 2
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TomFromTexas
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May 26, 2025 at 5:07 AM#1

Denied on prior authorisation twice, approved on the third attempt after a peer-to-peer, and the only thing that changed was who was doing the talking.

What I am trying to establish is what actually works on a prior-authorisation denial, as opposed to the list of things that sound like they should work.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

5 8PharmD_Rodriguez, julia.endo, JessicaM_2024 and 2 others
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MikeFit_NJ
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May 26, 2025 at 5:13 AM#2

Taking the question as asked, rather than the general version of it. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.

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DoseLogDan
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May 26, 2025 at 5:19 AM#3
MikeFit_NJ said:
SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.

7 10mel_PDX, Dr.AddMedPHL, newstart_MO and 4 others
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MikeNYC_runner
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May 26, 2025 at 5:25 AM#4
TomFromTexas said:
Denied on prior authorisation twice, approved on the third attempt after a peer-to-peer, and the only thing that changed was who was doing the…

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of people never reach the dose the headline number came from.

Correct me if the detail matters more than I have assumed.

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PeptideChemSF
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May 26, 2025 at 5:58 AM#5

From the other side of the consultation, briefly.

My insurance denied my PA related to cost and coverage. Has anyone successfully appealed? I'm considering going compounded instead.

9 12BrianDallas92, labquiet_amy, emily_PDX and 6 others
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