Dr.EndoEP said:

Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Month 9 update on sleep apnoea: down 36 lbs from my starting weight of 251 lbs. Here's what's changed beyond the scale:

• No longer pre-diabetic (A1C normalized)
• Off blood pressure medication
• Can tie my shoes without getting winded
• Sleep apnea resolved — returned my CPAP
• Confidence level: through the roof

This medication has genuinely given me my life back. I'm not exaggerating. 🙌

pam_columbus said:

Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

Dr.EndoEP said:

Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Pushing back on Dr.EndoEP here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Worth separating that from tirzepatide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.