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Evidence-based GLP-1 & peptide discussion since 2023
ForumsClinical Trials & ResearchSURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience? Page 4

SURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience?

jason_paloalto Wed, Feb 18, 2026 at 8:14 AM 22 replies 986 viewsPage 4 of 5
Dr.GutHealth
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Feb 19, 2026 at 12:30 PM#16
Dr.RaviCardio said:
The useful move here is to separate what is established from what is widely repeated.

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

21 19VanRx_Mike, steve_okc, dave_SLC and 18 others
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LindaRN_retired
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Feb 19, 2026 at 4:15 PM#17
DataDave said:
If you are going to change something, change one thing and give it long enough to express itself.

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

22 20Dr.GutHealth, amsterdam_pete, LondonLisa and 19 others
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hyun_seoul
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Seoul, KR
Feb 19, 2026 at 8:00 PM#18

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Feb 20, 2026 at 12:00 AM
23 21MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 20 others
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TrialNerd_Beth
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Feb 19, 2026 at 11:45 PM#19
hyun_seoul said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

This matches mine closely enough to be worth saying so out loud.

24 22DoseLogDan, SleepFixSam, PurityPaulOR and 21 others
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mike_mod
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Feb 20, 2026 at 3:30 AM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.

46 19PurityPaulOR, MaxMetOK, MounjBrad and 43 others
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