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ForumsClinical Trials & ResearchNNC0519-0396: Novo next-gen oral GLP-1 — anyone have experience? Page 2

NNC0519-0396: Novo next-gen oral GLP-1 — anyone have experience?

EndoResFellow Sat, Jan 3, 2026 at 11:36 AM 15 replies 968 viewsPage 2 of 3
jason_paloalto
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Palo Alto, CA
Jan 3, 2026 at 12:58 PM#6

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Jan 3, 2026 at 5:58 PM
8 11tane_welly, Dr.PathRoch, mona_PHX and 5 others
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paul_denver
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May 2024
Denver, CO
Jan 3, 2026 at 1:30 PM#7

One thing that is still open after MASHdoc_SA’s answer:

Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?

Last edited: Jan 3, 2026 at 7:30 PM
9 12jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 6 others
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PharmHunterJen
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Jul 2024
Illinois
Jan 3, 2026 at 2:02 PM#8
jason_paloalto said:
Say what you would expect to see if you were wrong, before you look.

Adding the part of the answer the thread has not reached. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

10 13kevin_tulsa, Dr.PainCLE, mike_mealprep and 7 others
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EndoResFellow
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Jan 3, 2026 at 2:34 PM#9

Closing the loop on my own question.

Update — I went back to the injectable. Not because the tablet did not work, but because the fasting window and my mornings were never going to agree.

11 14NurseKim_ATL, paul_denver, TinaHashiRN and 8 others
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raj_cambridge
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Jun 2024
Cambridge, MA
Jan 3, 2026 at 5:07 PM#10
PharmHunterJen said:
Worth answering the question that was asked rather than the one behind it.

No disagreement with PharmHunterJen. One condition attached. The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest. Where it bites is in the first fortnight, when people conclude the tablet does nothing.

31 4RickReta_CO, PharmHunterJen, TomTeleRx and 28 others
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