Dr.AddMedPHL said:

The pharmacokinetics explain nearly every practical question asked here.

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

MounjBrad said:

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

Dr.AddMedPHL said:

The pharmacokinetics explain nearly every practical question asked here.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Happy to go further on any of that.

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.