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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and muscle preservation? Page 5

Has anyone dealt with tirzepatide and muscle preservation?

marcus_mpls Thu, Oct 31, 2024 at 4:36 AM 50 replies 2,916 viewsPage 5 of 10
A1cHero_PHX
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Nov 23, 2024 at 6:27 AM#21
MASHdoc_SA said:
Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.

Last edited: Nov 23, 2024 at 11:27 AM
37 10zoe_NC, Dr.ObesityLA, NurseKim_ATL and 34 others
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rick_sfbay
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Dec 2, 2024 at 7:33 AM#22
MASHdoc_SA said:
Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

Coming at MASHdoc_SA’s question from a different direction. The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0 g/kg of reference body weight, and not making the deficit larger than the training can support. Cardio does not protect lean mass and in a deep deficit competes with recovery.

Last edited: Dec 2, 2024 at 1:33 PM
38 11NicoleRaleigh, james_edin, FranDenver and 35 others
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josh_phd_bmore
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Dec 11, 2024 at 8:34 AM#23

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Dec 11, 2024 at 10:34 AM
39 12zoe_NC, Dr.ObesityLA, NurseKim_ATL and 36 others
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ben_calgary
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Dec 20, 2024 at 9:30 AM#24

Following on from MASHdoc_SA — and this may be the naive question:

What fraction of loss being lean mass is actually normal, because the numbers quoted here range from 10% to 40% and cannot all be right?

40 13JakeSmashed95, NauseaFreeNow, SteveThurs and 37 others
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LipidDoc_ATL
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Dec 29, 2024 at 10:20 AM#25
josh_phd_bmore said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

41 14KristenIndy, MarkLI_maint, Dr.PeteFamMed and 38 others
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