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ForumsRetatrutide & Triple AgonistsWill retatrutide be the first to break 25% weight loss in Phase 3? Page 5

Will retatrutide be the first to break 25% weight loss in Phase 3?

Dr.ObesityMed Sat, May 9, 2026 at 1:48 AM 23 replies 941 viewsPage 5 of 5
PeptideSynthNJ
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Princeton, NJ
May 13, 2026 at 12:40 AM#21

One thing that is still open after Dr.CardioMD’s answer:

How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?

16 14wanda_boise, NurseAsh_DET, BenResearch_OR and 13 others
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wei_SG
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Singapore, SG
May 14, 2026 at 5:23 AM#22
cory_ATX said:
Read four things before the headline number.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

17 15SaraMom3, Dr.MetabolicMD, RetaRick_CA and 14 others
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KarenAZ_mom
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May 15, 2026 at 10:07 AM#23
cory_ATX said:
Read four things before the headline number.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

18 16bri_stats, pete_manc_UK, anna.melb_AU and 15 others
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Dr.NateNeph
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May 16, 2026 at 2:52 PM#24
cory_ATX said:
Read four things before the headline number.

Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.

19 17B12Beth, RickReta_CO, PharmHunterJen and 16 others
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MASHdoc_SA
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San Antonio, TX
May 17, 2026 at 7:37 PM#25

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

20 18kate.chem, DataDave, Dr.GutHealth and 17 others
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