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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? Page 7

Will reta make sema and tirz obsolete?

andrew_nyc Sun, Apr 5, 2026 at 9:23 AM 33 replies 1,028 viewsPage 7 of 7
LarryQC_SD
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May 20, 2026 at 7:47 PM#31
jason_paloalto said:
Say what you would expect to see if you were wrong, before you look.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Last edited: May 20, 2026 at 8:47 PM
19 17NurseKim_ATL, paul_denver, TinaHashiRN and 16 others
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emily_PDX
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May 24, 2026 at 7:52 AM#32
jason_paloalto said:
Say what you would expect to see if you were wrong, before you look.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

20 18PharmD_Rodriguez, julia.endo, JessicaM_2024 and 17 others
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Dr.CardioMD
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May 27, 2026 at 7:56 PM#33

From the other side of the consultation, briefly. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Correct me if the detail matters more than I have assumed.

21 19tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 18 others
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tammy_FL
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May 31, 2026 at 7:57 AM#34
Dr.CardioMD said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

This matches mine closely enough to be worth saying so out loud.

22 20Dr.PainCLE, mike_mealprep, NicoleRaleigh and 19 others
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wei_SG
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Jun 3, 2026 at 7:57 PM#35
Dr.CardioMD said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

23 21JenPlateau, SallyK_inj, CryptoCarl and 20 others
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