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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)My appetite is literally gone is this normal at 10mg — November 2025 Page 5

My appetite is literally gone is this normal at 10mg — November 2025

PeptideSynthNJ Thu, May 30, 2024 at 7:10 AM 45 replies 2,266 viewsPage 5 of 9
JessicaH_TX
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Jun 2, 2024 at 5:09 PM#21
quinn_sf said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

47 20wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 44 others
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MikeFit_NJ
Senior Member
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Apr 2024
New Jersey
Jun 3, 2024 at 8:04 AM#22
quinn_sf said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

48 21marcus_mpls, DeniseRN_TPA, SandraNC_45 and 45 others
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DanielChem_CHI
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Mar 2024
Chicago, IL
Jun 3, 2024 at 10:59 PM#23
quinn_sf said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

Last edited: Jun 4, 2024 at 12:59 AM
49 22patPC_UT, Dr.DermMIA, fiona_VT and 46 others
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hyun_seoul
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Jul 2024
Seoul, KR
Jun 4, 2024 at 1:53 PM#24

Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

50 23BariatricNurseD, MASHdoc_SA, GenomicsKate and 47 others
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Dr.PathRoch
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Jun 5, 2024 at 4:47 AM#25
hyun_seoul said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Second this. I had assumed I was the exception until I read this.

1 24Dr.MetabolicMD
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