paige_pharma said:

The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Clinical perspective, offered as context rather than as advice. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

MASHdoc_SA said:

The mechanism is more central than most summaries suggest.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Correct me if the detail matters more than I have assumed.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.