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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — my results so far Page 3

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — my results so far

bri_stats Thu, May 2, 2024 at 9:47 PM 12 replies 2,138 viewsPage 3 of 3
Dr.RaviCardio
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May 4, 2024 at 3:49 PM#11
DebRD_ATL said:
The dose-response is real but shallow at the top.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

45 18pete_manc_UK, anna.melb_AU, mark_tokyo and 42 others
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Dr.PathRoch
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May 4, 2024 at 6:37 PM#12
SallyK_inj said:
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

This is exactly what I could not find anywhere else.

46 19InsuranceTom, WendyG_ATL, SaraMom3 and 43 others
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cory_ATX
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May 4, 2024 at 9:25 PM#13
DebRD_ATL said:
The dose-response is real but shallow at the top.

This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

47 20mona_PHX, andrew_nyc, Dr.EndoEP and 44 others
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PeptideSynthNJ
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May 5, 2024 at 12:13 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

48 21MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 45 others
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Admin
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May 5, 2024 at 3:01 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

49 22PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 46 others
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