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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsRetatrutide cholesterol effects — need advice Page 3

Retatrutide cholesterol effects — need advice

labquiet_amy Sun, Mar 16, 2025 at 3:28 AM 56 replies 2,312 viewsPage 3 of 12
Dr.SleepRoch
Senior Member
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Mar 18, 2025 at 6:16 AM#11
Dr.ReproEndo said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.4% to 8.9% over 13 months.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1625925Particle count (more precise than LDL-C)
Small dense LDL65%29%Atherogenic pattern
Remnant cholesterol3314Triglyceride-rich lipoproteins
oxLDL7043Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

36 9sarah_TO, wendy_avl, jason_paloalto and 33 others
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tommy_boulder
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Nov 2024
Boulder, CO
Mar 19, 2025 at 1:52 PM#12
pete_RVA said:
Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale.

Thank you for spelling out the reasoning rather than just the conclusion.

37 10TinaHashiRN, robert_kc, dan_philly and 34 others
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JessicaM_2024
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Portland, OR
Mar 20, 2025 at 9:27 PM#13
Dr.ReproEndo said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.4% to 8.9% over 13 months.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

38 11mike_mealprep, NicoleRaleigh, james_edin and 35 others
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DataDave
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Apr 2024
Washington
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Mar 22, 2025 at 5:02 AM#14
labquiet_amy said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 13moChange
MetabolicA1C7.2%5.5%⬇️ 1.4%
MetabolicFasting Glucose12190⬇️ 26
LipidsLDL14993⬇️ 41
LipidsTriglycerides221111⬇️ 111
InflammationhsCRP6.50.9⬇️ 5.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

39 12amsterdam_pete, LondonLisa, mike_nyc and 36 others
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mike_mod
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Mar 23, 2025 at 12:36 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

40 13PurityPaulOR, MaxMetOK, MounjBrad and 37 others
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