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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsPatient preference: weekly injection vs potential monthly depot — 6 month update Page 3

Patient preference: weekly injection vs potential monthly depot — 6 month update

JakeBK_lifts Wed, Mar 5, 2025 at 11:56 AM 13 replies 1,602 viewsPage 3 of 3
LarryQC_SD
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Mar 5, 2025 at 9:26 PM#11
NurseKim_ATL said:
It helps to ask what evidence would change your mind before you look at any.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Mar 5, 2025 at 10:26 PM
29 2NurseKim_ATL, paul_denver, TinaHashiRN and 26 others
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dan_philly
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Mar 6, 2025 at 2:15 AM#12
A1cHero_PHX said:
The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

30 3AmyNC_wife, SkepticalSean, Dr.CardioMD and 27 others
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matt_MKE
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Milwaukee, WI
Mar 6, 2025 at 7:04 AM#13
NurseKim_ATL said:
It helps to ask what evidence would change your mind before you look at any.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Correct me if the detail matters more than I have assumed.

Last edited: Mar 6, 2025 at 10:04 AM
31 4GraceAZ_72, carl_compliance, DanielChem_CHI and 28 others
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hank_denver
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Mar 6, 2025 at 11:53 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

32 5fiona_VT, denise_HTX, raj_cambridge and 29 others
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mike_mod
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Mar 6, 2025 at 4:42 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

33 6PurityPaulOR, MaxMetOK, MounjBrad and 30 others
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