PeptideSynthNJ said:

Practical: whatever you change, write down the date and the reason.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

PeptideSynthNJ said:

Practical: whatever you change, write down the date and the reason.

Genuinely useful, thank you. I had the facts and not the framework.

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. No action needed from anybody.

mike_nyc said:

That is right, and it stops being right at the edges.

This matches mine closely enough to be worth saying so out loud.

mike_nyc said:

That is right, and it stops being right at the edges.

Coming at mike_nyc’s question from a different direction. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.