One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
One thing that is still open after LindaRN_retired’s answer:
Why adding glucagon agonism to an anti-obesity drug is not self-defeating, given that glucagon raises blood glucose?
Dr.NateNeph said:Practical: whatever you change, write down the date and the reason.
There is a second half to this that has not been said yet. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.
Ask again with the specifics and you will get a better answer than this one.
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Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.
CarlaRPh_TPA said:The useful move here is to separate what is established from what is widely repeated.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.