PharmacoVig_BOS said:Practical: whatever you change, write down the date and the reason.
Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.
Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
Dr.CardioMD said:If two explanations both fit, the useful question is which one predicts something the other does not.
Second this.
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Shop Reference StandardsDr.CardioMD said:If two explanations both fit, the useful question is which one predicts something the other does not.
There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.