Dr.RaviCardio said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
wanda_boise said:The pharmacokinetics explain nearly every practical question asked here.
Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.
Dr.RaviCardio said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
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Shop Reference StandardsAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
If somebody has the primary source to hand I would rather cite it than paraphrase it.