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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseDe novo lipogenesis reduction on GLP-1 — mechanistic hepatology Page 3

De novo lipogenesis reduction on GLP-1 — mechanistic hepatology

MASHdoc_SA Mon, Jun 1, 2026 at 1:48 AM 17 replies 523 viewsPage 3 of 4
Dr.PathRoch
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Rochester, MN
Jun 2, 2026 at 5:10 AM#11
VendorMark said:
Liver ultrasound comparison for liver and MASH: my hepatologist ordered serial ultrasounds to track NAFLD regression.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

Last edited: Jun 2, 2026 at 11:10 AM
3 1MikeFit_NJ, InsuranceTom, WendyG_ATL
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pete_nash
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Aug 2024
Nashville, TN
Jun 2, 2026 at 9:15 AM#12

Clinical perspective, offered as context rather than as advice. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Jun 2, 2026 at 3:15 PM
4 2Dr.Martinez, mike_mod, SarahChen_PharmD and 1 other
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anders_CPH
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Feb 2024
Copenhagen, DK
Jun 2, 2026 at 1:20 PM#13
JenPlateau said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

This is where I part company with the consensus forming above. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

5 3AussieAnna, BethLabQueen, ChrisMacros and 2 others
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NicoleRaleigh
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Aug 2024
Raleigh, NC
Jun 2, 2026 at 5:25 PM#14

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

6 4VendorMark, COA_Karl, MikeFit_NJ and 3 others
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mike_mod
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Jun 2, 2026 at 9:29 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

7 5PurityPaulOR, MaxMetOK, MounjBrad and 4 others
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