claudia_zurich said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
TomFromTexas said:The mechanism is more central than most summaries suggest.
Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.
claudia_zurich said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.
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Shop Reference StandardsOne concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.